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Consortium of Swiss Academic Libraries

The computational structure of environmental life cycle costing

Moreau, Vincent ; Weidema, Bo

In: The International Journal of Life Cycle Assessment, 2015, vol. 20, no. 10, p. 1359-1363

Consortium of Swiss Academic Libraries

Skyrme-Faddeev Instantons on Complex Surfaces

Slobodeanu, R. ; Svensson, M.

In: Communications in Mathematical Physics, 2015, vol. 335, no. 1, p. 83-91

Université de Fribourg

Profiling parvalbumin interneurons using iPSC: challenges and perspectives for Autism Spectrum Disorder (ASD)

Filice, Federica ; Schwaller, Beat ; Michel, Tanja M. ; Grünblatt, Edna

In: Molecular Autism, 2020, vol. 11, no. 1, p. 10

Autism spectrum disorders (ASD) are persistent conditions resulting from disrupted/altered neurodevelopment. ASD multifactorial etiology—and its numerous comorbid conditions—heightens the difficulty in identifying its underlying causes, thus obstructing the development of effective therapies. Increasing evidence from both animal and human studies suggests an altered functioning of the...

Université de Fribourg

Phosphoproteomic profiling reveals a defined genetic program for osteoblastic lineage commitment of human bone marrow–derived stromal stem cells

Barrio-Hernandez, Inigo ; Jafari, Abbas ; Rigbolt, Kristoffer T.G. ; Hallenborg, Philip ; Sanchez-Quiles, Virginia ; Skovrind, Ida ; Akimov, Vyacheslav ; Kratchmarova, Irina ; Dengjel, Jörn ; Kassem, Moustapha ; Blagoev, Blagoy

In: Genome Research, 2020, vol. 30, no. 1, p. 127-137

Bone marrow–derived mesenchymal stem cells (MSCs) differentiate into osteoblasts upon stimulation by signals present in their niche. Because the global signaling cascades involved in the early phases of MSCs osteoblast (OB) differentiation are not well-defined, we used quantitative mass spectrometry to delineate changes in human MSCs proteome and phosphoproteome during the first 24 h of...

Università della Svizzera italiana

Enhancing coevolution-based contact prediction by imposing structural self-consistency of the contacts

Kassem, Maher M. ; Christoffersen, Lars B. ; Cavalli, Andrea ; Lindorff-Larsen, Kresten

In: Scientific reports, 2018, vol. 8, no. 1, p. 11112

Based on the development of new algorithms and growth of sequence databases, it has recently become possible to build robust higher-order sequence models based on sets of aligned protein sequences. Such models have proven useful in de novo structure prediction, where the sequence models are used to find pairs of residues that co-vary during evolution, and hence are likely to be in spatial...

Université de Fribourg

Annexin A7 is required for ESCRT III-mediated plasma membrane repair

Sønder, Stine Lauritzen ; Boye, Theresa Louise ; Tölle, Regine ; Dengjel, Jörn ; Maeda, Kenji ; Jäättelä, Marja ; Simonsen, Adam Cohen ; Jaiswal, Jyoti K. ; Nylandsted, Jesper

In: Scientific Reports, 2019, vol. 9, no. 1, p. 6726

The plasma membrane of eukaryotic cells forms the essential barrier to the extracellular environment, and thus plasma membrane disruptions pose a fatal threat to cells. Here, using invasive breast cancer cells we show that the Ca2+ - and phospholipid-binding protein annexin A7 is part of the plasma membrane repair response by enabling assembly of the endosomal sorting complex required for ...