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Université de Fribourg

Bacterial oxidases of the cytochrome bd family : redox enzymes of unique structure, function, and utility as drug targets

Borisov, Vitaliy B. ; Siletsky, Sergey A. ; Paiardini, Alessandro ; Hoogewijs, David ; Forte, Elena ; Giuffrè, Alessandro ; Poole, Robert K.

In: Antioxidants & Redox Signaling, 2021, vol. 34, no. 16, p. 1280-1318

Significance: Cytochrome bd is a ubiquinol:oxygen oxidoreductase of many prokaryotic respiratory chains with a unique structure and functional characteristics. Its primary role is to couple the reduction of molecular oxygen, even at submicromolar concentrations, to water with the generation of a proton motive force used for adenosine triphosphate production. Cytochrome bd is found in many ...

Université de Fribourg

Arginase‐II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling

Yu, Yi ; Ladeiras, Diogo ; Xiong, Yuyan ; Boligan, Kayluz Frias ; Liang, Xiujie ; Gunten, Stephan ; Hunger, Robert E. ; Ming, Xiu‐Fen ; Yang, Zhihong

In: Journal of Cellular Physiology, 2020, p. jcp.29814

Elevated arginase type II (Arg‐II) associates with higher grade tumors. Its function and underlying molecular mechanisms in melanoma remain elusive. In the present study, we observed a significantly higher frequency of Arg‐II expression in melanoma of patients with metastasis than those without metastasis. Silencing Arg‐II in two human melanoma cell lines slowed down the cell growth,...