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Université de Fribourg

Environmental enrichment decreases chronic psychosocial stress-impaired extinction and reinstatement of ethanol conditioned place preference in C57BL/6 male mice

Bahi, Amine ; Dreyer, Jean-Luc

In: Psychopharmacology, 2019, p. -

During the last few decades, alcohol use disorders (AUD) have reached an epidemic prevalence, yet social influences on alcoholism have not been fully addressed. Several factors can modulate alcohol intake. On one hand, stress can reinforce ethanol-induced behaviors and be an important component in AUD and alcoholism. On the other hand, environmental enrichment (EE) has a neuroprotective role...

Université de Fribourg

Cardiovascular responses to a glucose drink in young male individuals with overweight/obesity and mild alterations in glucose metabolism, but without impaired glucose tolerance

Monnard, Cathriona R. ; Grasser, Erik Konrad

In: European Journal of Nutrition, 2019, p. -

Little is known about whether mild aberrations in glucose metabolism, which are seen in overweight/obese subjects (OW/OB) without impaired glucose tolerance, affect regulator control elements for blood pressure homeostasis. Methods Hence, we measured in age-matched male subjects with normal weight (n = 16; BMI = 22.4 kg m−2) and OW/OB (n = 11; BMI = 28.6 kg m−2) continuous...

Université de Neuchâtel

Towards the democratization of ontological modeling through a new pervasive means of representation

Baset, Selena ; Stoffel, Kilian (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2019 ; 2787.

Despite their proven utility in various areas of knowledge engineering, ontologies are falling short of reaching an equal position as formal domain models in the landscape of enterprise software development. With the ultimate goal of making ontologies more accessible to a wider audience of software development stakeholders, this thesis investigates the reasons that are still standing between...

Università della Svizzera italiana

Enrichment of intestinal Lactobacillus by enhanced secretory IgA coating alters glucose homeostasis in P2rx7-/- mice

Perruzza, Lisa ; Strati, Francesco ; Gargari, Giorgio ; D’Erchia, Anna Maria ; Fosso, Bruno ; Pesole, Graziano ; Guglielmetti, Simone ; Grassi, Fabio

In: Scientific reports, 2019, vol. 9, p. 9315

The secretory immunoglobulin A (SIgA) in mammalian gut protects the organism from infections and contributes to host physiology by shaping microbiota composition. The mechanisms regulating the adaptive SIgA response towards gut microbes are poorly defined. Deletion of P2rx7, encoding for the ATP-gated ionotropic P2X7 receptor, leads to T follicular helper (Tfh) cells expansion in the Peyer’s...

Université de Fribourg

Effect of different loading conditions on running mechanics at different velocities

Carretero-Navarro, Germán ; Márquez, Gonzalo ; Cherubini, Doménico ; Taube, Wolfgang

In: European Journal of Sport Science, 2019, vol. 19, no. 5, p. 595–602

Weighted vests are widely used to improve running economy and performance. However, it is not well-studied how running mechanics are adapted to counteract the higher peak vertical ground reaction forces (Fpeak) while running with such a device. Therefore, the present study aimed to investigate the effects of different loading conditions on running mechanics at different velocities. Thirteen...