In: The Journal of Clinical Endocrinology & Metabolism, 2016, vol. 101, no. 12, p. 4789-4798
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In: Antioxidants & Redox Signaling, 2021, vol. 34, no. 16, p. 1280-1318
Significance: Cytochrome bd is a ubiquinol:oxygen oxidoreductase of many prokaryotic respiratory chains with a unique structure and functional characteristics. Its primary role is to couple the reduction of molecular oxygen, even at submicromolar concentrations, to water with the generation of a proton motive force used for adenosine triphosphate production. Cytochrome bd is found in many ...
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In: Accounts of Chemical Research, 2019, vol. 52, no. 11, p. 3087–3096
The regulatory chemical mechanisms of lipid trafficking and degradation are involved in many pathophysiological processes, being implicated in severe pain, inflammation, and cancer. In addition, the processing of lipids is also relevant for industrial and environmental applications. However, there is poor understanding of the chemical features that control lipid membrane trafficking and allow...
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In: Scientific reports, 2018, vol. 8, p. 14683
Pyruvate (PYR) dehydrogenase complex (PDC) is an enzymatic system that plays a crucial role in cellular metabolism as it controls the entry of carbon into the Krebs cycle. From a structural point of view, PDC is formed by three different subunits (E1, E2 and E3) capable of catalyzing the three reaction steps necessary for the full conversion of pyruvate to acetyl-CoA. Recent investigations...
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In: Applied Microbiology and Biotechnology, 2014, vol. 98, no. 24, p. 9931-9952
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In: Cellular and Molecular Life Sciences, 2014, vol. 71, no. 17, p. 3311-3325
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In: Molecular biology of the cell, 2015, vol. 26, no. 19, p. 3373-3556
The endoplasmic reticulum (ER) is the site of maturation for secretory and membrane proteins in eukaryotic cells. The lumen of the mammalian ER contains >20 members of the protein disulfide isomerase (PDI) superfamily, which ensure formation of the correct set of intramolecular and intermolecular disulfide bonds as crucial, rate-limiting reactions of the protein folding process. Components of...
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In: Topics in Catalysis, 2013, vol. 56, no. 1-8, p. 19-22
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In: Monatshefte für Chemie / Chemical Monthly, 2005, vol. 136, no. 7, p. 1205-1219
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In: Applied Biochemistry and Biotechnology, 2000, vol. 83, no. 1-3, p. 183-193
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