Perfeziona i miei risultati

Lingua

Université de Fribourg

Tissue-specific isoforms of the single C. elegans Ryanodine receptor gene unc-68 control specific functions

Marques, Filipe ; Thapliyal, Saurabh ; Javer, Avelino ; Shrestha, Priyanka ; Brown, André E. X. ; Glauser, Dominique A.

In: PLOS Genetics, 2020, vol. 16, no. 10, p. e1009102

Ryanodine receptors (RyR) are essential regulators of cellular calcium homeostasis and signaling. Vertebrate genomes contain multiple RyR gene isoforms, expressed in different tissues and executing different functions. In contrast, invertebrate genomes contain a single RyR-encoding gene and it has long been proposed that different transcripts generated by alternative splicing may diversify...

Université de Fribourg

No evidence that frontal optical flow affects perceived locomotor speed and locomotor biomechanics when running on a treadmill

Caramenti, Martina ; Lafortuna, Claudio L. ; Mugellini, Elena ; Khaled, Omar Abou ; Bresciani, Jean-Pierre ; Dubois, Amandine

In: Applied Sciences, 2019, vol. 9, no. 21, p. 4589

We investigated how the presentation and the manipulation of an optical flow while running on a treadmill affect perceived locomotor speed (Experiment 1) and gait parameters (Experiment 2). In Experiment 1, 12 healthy participants were instructed to run at an imposed speed and to focus on their sensorimotor sensations to be able to reproduce this running speed later. After a pause, they had...

Université de Fribourg

Regular physical activity modulates perceived visual speed when running in treadmill-mediated virtual environments

Caramenti, Martina ; Lafortuna, Claudio L. ; Mugellini, Elena ; Khaled, Omar Abou ; Bresciani, Jean-Pierre ; Dubois, Amandine

In: PLOS ONE, 2019, vol. 14, no. 6, p. e0219017

In virtual reality, visual speed is usually underestimated relative to locomotor speed. Here we investigated how physical activity and fitness affect perceived visual speed when running in a treadmill-mediated virtual environment. Thirty healthy participants (ten sedentary individuals, ten team sport players and ten expert runners) ran on a treadmill at two different speeds (8, 12km/h) in...

Université de Fribourg

Low 24-hour core body temperature as a thrifty metabolic trait driving catch-up fat during weight regain after caloric restriction

Calonne, Julie ; Arsenijevic, Denis ; Scerri, Isabelle ; Miles-Chan, Jennifer L. ; Montani, Jean-Pierre ; Dulloo, Abdul G.

In: American Journal of Physiology-Endocrinology and Metabolism, 2019, vol. 317, no. 4, p. E699–E709

The recovery of body weight after substantial weight loss or growth retardation is often characterized by a disproportionately higher rate of fat mass vs. lean mass recovery, with this phenomenon of “preferential catch-up fat” being contributed by energy conservation (thrifty) metabolism. To test the hypothesis that a low core body temperature (Tc) constitutes a thrifty metabolic trait...

Université de Fribourg

Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

Formento, Emanuele ; Minassian, Karen ; Wagner, Fabien ; Mignardot, Jean Baptiste ; Le Goff-Mignardot, Camille G. ; Rowald, Andreas ; Bloch, Jocelyne ; Micera, Silvestro ; Capogrosso, Marco ; Courtine, Gregoire

In: Nature Neuroscience, 2018, vol. 21, no. 12, p. 1728–1741

Epidural electrical stimulation (EES) of the spinal cord restores locomotion in animal models of spinal cord injury but is less effective in humans. Here we hypothesized that this interspecies discrepancy is due to interference between EES and proprioceptive information in humans. Computational simulations and preclinical and clinical experiments reveal that EES blocks a significant amount of...

Université de Fribourg

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Capogrosso, Marco ; Wagner, Fabien B. ; Gandar, Jerome ; Moraud, Eduardo Martin ; Wenger, Nikolaus ; Milekovic, Tomislav ; Shkorbatova, Polina ; Pavlova, Natalia ; Musienko, Pavel ; Bezard, Erwan ; Bloch, Jocelyne ; Courtine, Grégoire

In: Nature Protocols, 2018, vol. 13, no. 9, p. 2031–2061

Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipment and surgical procedures that can be used to acquire chronic electromyographic (EMG) recordings from leg muscles and to implant targeted...