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Università della Svizzera italiana

Enhancing multi-scale cardiac simulations by coupling electrophysiology and mechanics : a flexible high performance approach to cardiac electromechanics

Pozzi, Sonia ; Krause, Rolf (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019INFO005.

This work focuses on the development of computational methods for the simulation of the propagation of the electrical potential in the heart and of the resulting mechanical contraction. The interaction of these two physical phenomena is described by an electromechanical model which consists of the monodomain system, which describes the propagation of the action potential in the cardiac tissue,...

Public access from 1-set-2019
Consortium of Swiss Academic Libraries

A new interpolation-free procedure for breath-by-breath analysis of oxygen uptake in exercise transients

Bringard, Aurélien ; Adami, Alessandra ; Moia, Christian ; Ferretti, Guido

In: European Journal of Applied Physiology, 2014, vol. 114, no. 9, p. 1983-1994

Public access from 1-ott-2019
Consortium of Swiss Academic Libraries

Editorial

Araújo, N. ; Mendoza Jiménez, M. ; Wittel, F.

In: The European Physical Journal Special Topics, 2014, vol. 223, no. 11, p. 2063-2064

Public access from 1-ago-2019
Consortium of Swiss Academic Libraries

Assembly and nuclear export of pre-ribosomal particles in budding yeast

Gerhardy, Stefan ; Menet, Anna ; Peña, Cohue ; Petkowski, Janusz ; Panse, Vikram

In: Chromosoma, 2014, vol. 123, no. 4, p. 327-344

Université de Fribourg

Valuable carcasses: postmortem preservation of fatty acid composition in heart tissue

Currie, Shannon E. ; Mène-Saffrané, Laurent ; Fasel, Nicolas J.

In: Conservation Physiology, 2019, vol. 7, no. 1, p. -

In order to effectively conserve species, we must understand the structure and function of integral mechanisms at all levels of organismal organisation, from intracellular biochemistry to whole animal ecophysiology. The accuracy of biochemical analyses depend on the quality and integrity of the samples analysed. It is believed that tissue samples collected immediately postmortem provide the...

Université de Fribourg

Drosophila germ-line modulation of insulin signaling and lifespan

Flatt, Thomas ; Min, Kyung-Jin ; D'Alterio, Cecilia ; Villa-Cuesta, Eugenia ; Cumbers, John ; Lehmann, Ruth ; Jones, D. Leanne ; Tatar, Marc

In: Proceedings of the National Academy of Sciences of the United States of America, 2008, vol. 105, no. 17, p. 6368–6373

Ablation of germ-line precursor cells in Caenorhabditis elegans extends lifespan by activating DAF-16, a forkhead transcription factor (FOXO) repressed by insulin/insulin-like growth factor (IGF) signaling (IIS). Signals from the gonad might thus regulate whole-organism aging by modulating IIS. To date, the details of this systemic regulation of aging by the reproductive system are not...

Université de Fribourg

Living long and well: prospects for a personalized approach to the medicine of ageing

Fuellen G. ; Schofield P. ; Flatt Thomas ; Schulz R.-J. ; Boege F. ; Kraft K. ; Rimbach G. ; Ibrahim S. ; Tietz A. ; Schmidt C. ; Köhling R. ; Simm A.

In: Gerontology, 2016, vol. 62, no. 4, p. 409–416

Research into ageing and its underlying molecular basis enables us to develop and implement targeted interventions to ameliorate or cure its consequences. However, the efficacy of interventions often differs widely between individuals, suggesting that populations should be stratified or even individualized. Large-scale cohort studies in humans, similar systematic studies in model organisms as...