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Université de Fribourg

Silica nanoparticles enhance disease resistance in Arabidopsis plants

El-Shetehy, Mohamed ; Moradi, Aboubakr ; Maceroni, Mattia ; Reinhardt, Didier ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Mauch, Felix ; Schwab, Fabienne

In: Nature Nanotechnology, 2020, p. 1–10

In plants, pathogen attack can induce an immune response known as systemic acquired resistance that protects against a broad spectrum of pathogens. In the search for safer agrochemicals, silica nanoparticles (SiO2 NPs; food additive E551) have recently been proposed as a new tool. However, initial results are controversial, and the molecular mechanisms of SiO2 NP-induced disease resistance...

Université de Fribourg

Shear stress-responsive polymersome nanoreactors inspired by the marine bioluminescence of dinoflagellates

Rifaie‐Graham, Omar ; Galensowske, Nikolas F. B. ; Dean, Charlie ; Pollard, Jonas ; Balog, Sandor ; Gouveia, Micael G. ; Chami, Mohamed ; Vian, Antoine ; Amstad, Esther ; Lattuada, Marco ; Bruns, Nico

In: Angewandte Chemie International Edition, 2020, vol. 60, no. 2, p. 904-909

Some marine plankton called dinoflagellates emit light in response to the movement of surrounding water, resulting in a phenomenon called milky seas or sea sparkle. The underlying concept, a shear-stress induced permeabilisation of biocatalytic reaction compartments, is transferred to polymer-based nanoreactors. Amphiphilic block copolymers that carry nucleobases in their hydrophobic block...

Université de Fribourg

Increased uptake of silica nanoparticles in inflamed macrophages but not upon co-exposure to micron-sized particles

Susnik, Eva ; Taladriz-Blanco, Patricia ; Drasler, Barbara ; Balog, Sandor ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Cells, 2020, vol. 9, no. 9, p. 2099

Silica nanoparticles (NPs) are widely used in various industrial and biomedical applications. Little is known about the cellular uptake of co-exposed silica particles, as can be expected in our daily life. In addition, an inflamed microenvironment might affect a NP’s uptake and a cell’s physiological response. Herein, prestimulated mouse J774A.1 macrophages with bacterial...

Université de Fribourg

When plants and plastic interact

Schwab, Fabienne ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Nature Nanotechnology, 2020, vol. 15, no. 9, p. 729–730

Overcoming the challenges of plastic detection in plants has made it possible to transfer many of the lessons learned from plant–metal nanoparticle interactions to plastic nanoparticles.

Université de Fribourg

Rapid and sensitive quantification of cell-associated multi-walled carbon nanotubes

Steinmetz, Lukas ; Bourquin, Joel ; Barosova, Hana ; Haeni, Laetitia ; Caldwell, Jessica ; Milosevic, Ana ; Geers, Christoph ; Bonmarin, Mathias ; Taladriz-Blanco, Patricia ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Nanoscale, 2020, vol. 12, no. 33, p. 17362–17372

Evaluating nanomaterial uptake and association by cells is relevant for in vitro studies related to safe-by-design approaches, nanomedicine or applications in photothermal therapy. However, standard analytical techniques are time-consuming, involve complex sample preparation or include labelling of the investigated sample system with e.g. fluorescent dyes. Here, we explore lock-in...

Université de Fribourg

Holistic view on cell survival and dna damage: how model-based data analysis supports exploration of dynamics in biological systems

Weyland, Mathias S. ; Thumser-Henner, Pauline ; Nytko, Katarzyna J. ; Rohrer Bley, Carla ; Ulzega, Simone ; Petri-Fink, Alke ; Lattuada, Marco ; Füchslin, Rudolf M. ; Scheidegger, Stephan

In: Computational and Mathematical Methods in Medicine, 2020, vol. 2020, p. 1–11

In this work, a method is established to calibrate a model that describes the basic dynamics of DNA damage and repair. The model can be used to extend planning for radiotherapy and hyperthermia in order to include the biological effects. In contrast to “syntactic” models (e.g., describing molecular kinetics), the model used here describes radiobiological semantics, resulting in a more...

Université de Fribourg

Particle surfaces to study macrophage adherence, migration, and clearance

Septiadi, Dedy ; Lee, Aaron ; Spuch‐Calvar, Miguel ; Moore, Thomas Lee ; Spiaggia, Giovanni ; Abdussalam, Wildan ; Rodriguez‐Lorenzo, Laura ; Taladriz‐Blanco, Patricia ; Rothen‐Rutishauser, Barbara ; Petri‐Fink, Alke

In: Advanced Functional Materials, 2020, p. 2002630

Nanoparticle adsorption to substrates pose a unique challenge to understand uptake mechanisms as it involves the organization of complex cytoskeletal components by cells to perform endocytosis/phagocytosis. In particular, it is not well‐understood from a cell mechanics perspective how the adhesion of particles on substrate will influence the ease of material clearance. By using a particle...