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Università della Svizzera italiana

Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome

Cassani, Barbara ; Poliani, Pietro Luigi ; Marrella, Veronica ; Schena, Francesca ; Sauer, Aisha V. ; Ravanini, Maria ; Strina, Dario ; Busse, Christian E. ; Regenass, Stephan ; Wardemann, Hedda ; Martini, Alberto ; Facchetti, Fabio ; Burg, Mirjam van der ; Rolink, Antonius G. ; Vezzoni, Paolo ; Grassi, Fabio ; Traggiai, Elisabetta ; Villa, Anna

In: Journal of experimental medicine, 2010, vol. 207, no. 7, p. 1525-1540

Hypomorphic RAG mutations, leading to limited V(D)J rearrangements, cause Omenn syndrome (OS), a peculiar severe combined immunodeficiency associated with autoimmune-like manifestations. Whether B cells play a role in OS pathogenesis is so far unexplored. Here we report the detection of plasma cells in lymphoid organs of OS patients, in which circulating B cells are undetectable. Hypomorphic...

Université de Fribourg

A resazurin reduction-based assay for rapid detection of polymyxin resistance in Acinetobacter baumannii and Pseudomonas aeruginosa

Lescat, Mathilde ; Poirel, Laurent ; Tinguely, Camille ; Nordmann, Patrice

In: Journal of Clinical Microbiology, 2018, p. -

A rapid test was developed for identification of polymyxin resistance in non-fermenting bacteria. This test detects viable cells after growth in a medium containing a defined concentration of colistin. The principle of this test is based on the visual detection of the reduction of the resazurin reagent, a viability colorant, observed by its color change (blue to purple or pink). Its...

Université de Fribourg

Comparative study of nonequilibrium insulator-to-metal transitions in electron-phonon systems

Sayyad, Sharareh ; Žitko, Rok ; Strand, Hugo U. R. ; Werner, Philipp ; Golež, Denis

In: Physical Review B, 2019, vol. 99, no. 4, p. 045118

We study equilibrium and nonequilibrium properties of electron-phonon systems described by the Hubbard-Holstein model using dynamical mean-field theory. In equilibrium, we benchmark the results for impurity solvers based on the one-crossing approximation and slave-rotor approximation against non-perturbative numerical renormalization group reference data. We also examine how well the...

Université de Fribourg

Predicting perceptions of the lexical richness of short French, German, and Portuguese texts using text-based indices

Vanhove, Jan ; Bonvin, Audrey ; Lambelet, Amelia ; Berthele, Raphael

In: Journal of Writing Research, 2019, vol. 10, no. 3, p. 499-525

We investigated how well readers’ perceptions of the lexical richness of short texts can be predicted on the basis of automatically computable indices of the texts’ lexical properties. 3,060 French, German and Portuguese texts (between 9 and 284 words long) written by 8- to 10-year-olds were rated for their lexical richness by between 3 and 18 uninstructed raters, and over 150 indices were...

Université de Fribourg

The reproducibility of SfM algorithms to produce detailed Digital Surface Models: the example of PhotoScan applied to a high-alpine rock glacier

Hendrickx, Hanne ; Vivero, Sebastián ; Cock, Laure De ; De Wit, Bart ; De Maeyer, Philippe ; Lambiel, Christophe ; Delaloye, Reynald ; Nyssen, Jan ; Frankl, Amaury

In: Remote Sensing Letters, 2019, vol. 10, no. 1, p. 11–20

In geomorphology, PhotoScan is a software that is used to produce Digital Surface Models (DSMs). It constructs 3D environments from 2D imagery (often taken by Unmanned Aerial Vehicles (UAV)) based on Structure-from-Motion (SfM) and Multi- View Stereo (MVS) principles. However, unpublished computer-vision algorithms used, contain random elements which can affect the accuracy of the outputs. For...

Haute Ecole de Gestion & Tourisme

Analysis, design, and implementation of an infrastructure-less situation awareness application

Bonvin, Flavien ; Bocchi, Yann (Dir.)

Mémoire de bachelor : Haute Ecole de Gestion & Tourisme, 2018.

This work aims to implement an application based on opportunistic communication. It must be operational in a disaster situation when the cellular network is not available. During this work, a first part was consecrated to the study of the several types of ad hoc networks and the various technologies related to them. This has served as a foundation for the study of ad hoc networks in...

Université de Fribourg

Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system

Lannes, Nils ; Eppler, Elisabeth ; Etemad, Samar ; Yotovski, Peter ; Filgueira, Luis

In: Oncotarget, 2017, vol. 8, no. 69, p. 114393–114413

Microglia cells are the unique residential macrophages of the central nervous system (CNS). They have a special origin, as they derive from the embryonic yolk sac and enter the developing CNS at a very early stage. They play an important role during CNS development and adult homeostasis. They have a major contribution to adult neurogenesis and neuroinflammation. Thus, they participate in the...

Université de Fribourg

Revealing the pseudogap in ${\mathrm{Sr}}_{3}{({\mathrm{Ru}}_{0.985}{\mathrm{Fe}}_{0.015})}_{2}{\mathrm{O}}_{7}$ by optical spectroscopy

Ban, W. J. ; Xu, Bing ; Li, W. H. ; Wang, Y. ; Ge, J. J. ; Li, P. G. ; Yang, R. ; Dai, Y. M. ; Mao, Z. Q. ; Xiao, H.

In: Physical Review B, 2018, vol. 98, no. 20, p. 205111

We report resistivity, magnetization, and optical spectroscopy study on single-crystal sample of Sr3(Ru0.985Fe0.015 )2O7. An upturn is observed in resistivity at about 30 K. Below 30 K, the dip in resistivity R(ω), the suppression in scattering rate 1/τ (ω), the peaklike feature in optical conductivity σ1(ω), and the remainder of spectral weight all suggest the formation of a pseudogap....

Université de Fribourg

Characterization of the global network of optical magnetometers to search for exotic physics (GNOME)

Afach, S. ; Budker, D. ; Camp, G. De ; Dumont, V. ; Grujić, Zoran Dragan ; Guo, H. ; Jackson Kimball, D. F. ; Kornack, T. W. ; Lebedev, Victor ; Li, W. ; Masia-Roig, H. ; Nix, S. ; Padniuk, M. ; Palm, C. A. ; Pankow, C. ; Penaflor, A. ; Peng, X. ; Pustelny, Simon ; Scholtes, Theo ; Smiga, J. A. ; Stalnaker, J. E. ; Weis, Antoine ; Wickenbrock, A. ; Wurm, D.

In: Physics of the Dark Universe, 2018, vol. 22, p. 162–180

The Global Network of Optical Magnetometers to search for Exotic physics (GNOME) is a network of geographically separated, time-synchronized, optically pumped atomic magnetometers that is being used to search for correlated transient signals heralding exotic physics. The GNOME is sensitive to nuclear- and electron-spin couplings to exotic fields from astrophysical sources such as compact...

Université de Fribourg

Tunable 2D binary colloidal alloys for soft nanotemplating

Fernández-Rodríguez, Miguel Ángel ; Elnathan, Roey ; Ditcovski, Ran ; Grillo, Fabio ; Conley, Gaurasundar Marc ; Timpu, Flavia ; Rauh, Astrid ; Geisel, Karen ; Ellenbogen, Tal ; Grange, Rachel ; Scheffold, Frank ; Karg, Matthias ; Richtering, Walter ; Voelcker, Nicolas H. ; Isa, Lucio

In: Nanoscale, 2018, vol. 10, no. 47, p. 22189–22195

The realization of non-close-packed nanoscale patterns with multiple feature sizes and length scales via colloidal self-assembly is a highly challenging task. We demonstrate here the creation of a variety of tunable particle arrays by harnessing the sequential self-assembly and deposition of two differently sized microgel particles at the fluid–fluid interface. The two-step process is...