Université de Fribourg

αENaC mediated lithium absorption promotes nephrogenic diabetes insipidus

Mønster Christensen, Birgitte ; Mercier Zuber, Annie ; Loffing, Johannes ; Stehle, Jean-Christophe ; Deen, Peter M.T. ; Rossier, Bernard C. ; Hummler, Edith

In: Journal of the American Society of Nephrology, 2010, vol. 21, p. -

Lithium-induced nephrogenic diabetes insipidus (NDI) is accompanied by polyuria, downregulation of aquaporin 2 (AQP2), and cellular remodeling of the collecting duct (CD). The amiloride-sensitive epithelial sodium channel (ENaC) is a likely candidate for lithium entry. Here, we subjected transgenic mice lacking αENaC specifically in the CD (knockout [KO] mice) and littermate controls to chronic...

Université de Fribourg

Inhibition of the Kit ligand/c-Kit axis attenuates metastasis in a mouse model mimicking local breast cancer relapse after radiotherapy

Kuonen, Francois ; Laurent, Jullien ; Secondini, Chiara ; Lorusso, Girieca ; Stehle, Jean-Christophe ; Rausch, Thierry ; Hull, Eveline Faes-van't ; Bieler, Gregory ; Alghisi, Gian Carlo ; Schwendener, Reto A. ; Andrejevic-Blant, Snezana ; Mirimanoff, René-Olivier ; Ruegg, Curzio

In: Clinical Cancer Research, 2012, p. -

Purpose: Local breast cancer relapse after breast-saving surgery and radiotherapy is associated with increased risk of distant metastasis formation. The mechanisms involved remain largely elusive. We used the well-characterized 4T1 syngeneic, orthotopic breast cancer model to identify novel mechanisms of post-radiation metastasis. Experimental Design: 4T1 cells were injected in 20 Gy...