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The art of fin regeneration in zebrafish

Pfefferli, Catherine ; Jaźwińska, Anna

In: Regeneration, 2015, p. -

The zebrafish fin provides a valuable model to study the epimorphic type of regeneration, by which the amputated part of the appendage is nearly perfectly replaced. To accomplish fin regeneration, two reciprocally interacting domains need to be established at the injury site, namely, a wound epithelium and a blastema. The wound epithelium provides a supporting niche for the blastema, which...

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Induction of myocardial infarction in adult zebrafish using cryoinjury

Chablais, Fabian ; Jaźwińska, Anna

In: Journal of Visual Experiments, 2012, vol. 62, p. e3666

The mammalian heart is incapable of significant regeneration following an acute injury such as myocardial infarction. By contrast, urodele amphibians and teleost fish retain a remarkable capacity for cardiac regeneration with little or no scarring throughout life. It is not known why only some non-mammalian vertebrates can recreate a complete organ from remnant tissues. To understand the...

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