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The role of the acquired immune response in systemic sclerosis

Chizzolini, Carlo ; Boin, Francesco

In: Seminars in Immunopathology, 2015, vol. 37, no. 5, p. 519-528

Università della Svizzera italiana

Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis

Armas-González, Estefanía ; Domínguez-Luis, María Jesús ; Díaz-Martín, Ana ; Arce-Franco, Mayte ; Castro-Hernández, Javier ; Danelon, Gabriela ; Hernández-Hernández, Vanesa ; Bustabad-Reyes, Sagrario ; Cantabrana, Alberto ; Uguccioni ; Díaz-González, Federico

In: Arthritis research & therapy, 2018, vol. 20, p. 114

Background: B cells exert their pathogenic action in rheumatoid arthritis (RA) locally in the synovium. This study was undertaken to elucidate the chemokines responsible for the recruitment of B cells in the inflamed synovium, taking into account that the rich chemokine milieu present in the synovial tissue can fine-tune modulate discrete chemokine receptors. Methods: Expression levels of...

Università della Svizzera italiana

Expression of CXCL12 receptors in B cells from Mexican Mestizos patients with systemic lupus erythematosus

Biajoux, Vincent ; Bignon, Alexandre ; Freitas, Christelle ; Martinez, Valérie ; Thelen, Marcus ; Lima, Guadalupe ; Jakez-Ocampo, Juan ; Emilie, Dominique ; Llorente, Luis ; Balabanian, Karl

In: Journal of translational medicine, 2012, vol. 10, no. 1, p. 251-267

Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by B-cell hyperreactivity and the production of pathogenic anti-nuclear- directed auto-antibodies (Abs). B-cell ontogeny is partly dependent on the CXCL12/CXCR4 axis for which the contribution to SLE pathogenesis remains unclear. CXCR7, the novel receptor for CXCL12, is differentially expressed among...