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Université de Fribourg

Synthesis of a non-peptidic PET tracer designed for α5β1 integrin receptor

Monaco, Alessandra ; Michelin, Olivier ; Prior, John ; Rüegg, Curzio ; Scapozza, Leonardo ; Seimbille, Yann

In: Journal of labelled compounds & radiopharmaceuticals, 2014, vol. 57, no. 5, p. 365-370

Arginine–glycine–aspartic acid (RGD)-containing peptides have been traditionally used as PET probes to noninvasively image angiogenesis, but recently, small selective molecules for α₅β₁ integrin receptor have been developed with promising results. Sixty-one antagonists were screened, and tert-butyl...