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Université de Fribourg

Endothelial-specific deletion of Connexin40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion

Chadjichristos, C.E. ; Scheckenbach, K.E.L. ; Veen, T.A.B. van ; Richani Sarieddine, M.Z. ; Wit, C. de ; Yang, Zhihong ; Roth, I. ; Bacchetta, M. ; Viswambharan, Hema ; Foglia, B. ; Dudez, T. ; Kempen, M.J.A. van ; Coenjaerts, F.E.J. ; Miquerol, L. ; Deutsch, U. ; Jongsma, H.J. ; Chanson, M. ; Kwak, B.R.

In: Circulation, 2010, vol. 121, p. 123-131

Background— Endothelial dysfunction is the initiating event of atherosclerosis. The expression of connexin40 (Cx40), an endothelial gap junction protein, is decreased during atherogenesis. In the present report, we sought to determine whether Cx40 contributes to the development of the disease.Methods and Results— Mice with ubiquitous deletion of Cx40 are hypertensive, a risk factor for...

Université de Fribourg

O-linked β-N-acetylglucosamine during hyperglycemia exerts both anti-inflammatory and pro-oxidative properties in the endothelial system

Rajapakse, Angana Gupta ; Ming, Xiu-Fen ; Carvas, João Miguel ; Yang, Zhihong

In: Oxidative Medicine & Cellular Longevity, 2009, vol. 2, no. 3, p. 172-175

Elevated cellular levels of protein O-linked β-N-acetylglucosamine (O-GlcNAc) through hexosamine biosynthesis pathway (HBP) are suggested to contribute to cardiovascular adverse effects under chronic hyperglycemic condition associated with oxidative stress and inflammation. Conversely, enhancing O- GlcNAc levels have also been demonstrated being protective against myocardial ...

2 risultati 1