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The N276 glycosylation site is required for HIV-1 neutralization by the CD4 binding site specific HJ16 monoclonal antibody

Balla-Jhagjhoorsingh, Sunita S. ; Corti, Davide ; Heyndrickx, Leo ; Willems, Elisabeth ; Vereecken, Katleen ; Davis, David ; Vanham, Guido

In: Plos one, 2013, vol. 8, no. 7, p. e68863

Immunogen design for HIV-1 vaccines could be based on epitope identification of naturally occurring neutralizing antibodies in infected patients. A tier 2 neutralizing monoclonal antibody (mAb), HJ16 recognizes a new epitope in the CD4 binding site (CD4bs) region that only partially overlaps with the b12 epitope. We aimed to identify the critical binding site by resistance induction in a...