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Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation

Takizawa, Hitoshi ; Regoes, Roland R. ; Boddupalli, Chandra S. ; Bonhoeffer, Sebastian ; Manz, Markus G.

In: Journal of experimental medicine, 2011, vol. 208, no. 2, p. 273-284

Hematopoietic stem cells (HSCs) maintain blood production. How often mouse HSCs divide and whether each HSC contributes simultaneously, sequentially, or repetitively to hematopoiesis remains to be determined. We track division of 5-(and-6)-carboxyfluorescein diacetate succinimidyl ester (CFSE)–labeled HSC in vivo. We found that, in steady-state mice, bone marrow cells capable of...