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Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical collecting duct cells

Flores, Sandra Y. ; Loffing-Cueni, Dominique ; Kamynina, Elena ; Daidié, Dorothée ; Gerbex, Carole ; Chabanel, Sting ; Dudler, Jean ; Loffing, Johannes ; Staub, Olivier

In: Journal of the American Society of Nephrology, 2005, vol. 16, p. 2279

Aldosterone plays a central role in Na⁺ homeostasis by controlling Na⁺ reabsorption in the aldosterone-sensitive distal nephron involving the epithelial Na⁺ channel (ENaC). Part of the effects of aldosterone is mediated by serum and glucocorticoid-induced kinase 1 (Sgk1), a Ser/Thr kinase whose expression is rapidly induced by aldosterone and that increases in heterologous expression...