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Engrailed-2 regulates genes related to vesicle formation and transport in cerebellar Purkinje cells

Holst, Martin I. ; Maercker, Christian ; Pintea, Bogdan ; Masseroli, Marco ; Liebig, Christian ; Jankowski, Jakob ; Miething, Andreas ; Martini, Julia ; Schwaller, Beat ; Oberdick, John ; Schilling, Karl ; Baader, Stephan L.

In: Molecular and Cellular Neuroscience, 2008/38/4/10.1016/j.mcn.2008.04.010

Engrailed transcription factors regulate survival, cell fate decisions and axon pathfinding in central neurons. En-2 can also attenuate Purkinje cell (PC) maturation. Here, we use array analysis to scrutinize gene expression in developing PCs overexpressing Engrailed-2 (L7En-2). The majority (70%) of regulated genes was found down-regulated in L7En-2 cerebella, consistent with the known...