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Mechanism of capsaicin receptor TRPV1-mediated toxicity in pain-sensing neurons focusing on the effects of Na⁺/Ca2 + fluxes and the Ca2 +-binding protein calretinin

Pecze, László ; Blum, Walter ; Schwaller, Beat

In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013, vol. 1833, no. 7, p. 1680–1691

Transient receptor potential vanilloid subtype 1 (TRPV1) receptor is a pain-sensing, ligand-gated, non-selective cation channel expressed in peripheral sensory neurons. Prolonged activation of TRPV1 by capsaicin leads to cell swelling and formation of membrane blebs in rat dorsal root ganglion (DRG) neurons. Similar results were obtained in NIH3T3 fibroblast cells stably expressing TRPV1. Here,...

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The use of transgenic mouse models to reveal the functions of Ca² ⁺ buffer proteins in excitable cells

Schwaller, Beat

In: Biochimica et Biophysica Acta (BBA) - General Subjects, 2012, p. -

Background Cytosolic Ca² ⁺ buffers are members of the large family of Ca² ⁺-binding proteins and are essential components of the Ca² ⁺ signaling toolkit implicated in the precise regulation of intracellular Ca² ⁺ signals. Their physiological role in excitable cells has been investigated in vivo by analyzing the phenotype of mice either lacking one of the Ca² ⁺ buffers or...

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