Université de Fribourg

Fine manual dexterity assessment after autologous neural cell ecosystem (ANCE) transplantation in a non-human primate model of parkinson’s disease

Borgognon, Simon ; Cottet, Jérôme ; Moret, Véronique ; Chatagny, Pauline ; Carrara, Laura ; Fregosi, Michela ; Bloch, Jocelyne ; Brunet, Jean-François ; Rouiller, Eric M. ; Badoud, Simon

In: Neurorehabilitation and Neural Repair, 2019, vol. 33, no. 7, p. 553–567

Autologous neural cell ecosystem (ANCE) transplantation improves motor recovery in MPTP monkeys. These motor symptoms were assessed using semi-quantitative clinical rating scales, widely used in many studies. However, limitations in terms of sensitivity, combined with relatively subjective assessment of their different items, make inter-study comparisons difficult to achieve. Objective. The...

Université de Fribourg

Effects of dorsolateral prefrontal cortex lesion on motor habit and performance assessed with manual grasping and control of force in macaque monkeys

Badoud, Simon ; Borgognon, Simon ; Cottet, Jérôme ; Chatagny, Pauline ; Moret, Véronique ; Fregosi, Michela ; Kaeser, Mélanie ; Fortis, Ekaterina ; Schmidlin, Eric ; Bloch, Jocelyne ; Brunet, Jean-François ; Rouiller, Eric M.

In: Brain Structure and Function, 2017, vol. 222, no. 3, p. 1193–1206

In the context of an autologous adult neural cell ecosystem (ANCE) transplantation study, four intact adult female macaque monkeys underwent a unilateral biopsy of the dorsolateral prefrontal cortex (dlPFC) to provide the cellular material needed to obtain the ANCE. Monkeys were previously trained to perform quantitative motor (manual dexterity) tasks, namely, the “modified-Brinkman...

Université de Fribourg

Distinction between hand dominance and hand preference in primates: a behavioral investigation of manual dexterity in nonhuman primates (macaques) and human subjects

Chatagny, Pauline ; Badoud, Simon ; Kaeser, Mélanie ; Gindrat, Anne-Dominique ; Savidan, Julie ; Fregosi, Michela ; Moret, Véronique ; Roulin, Christine ; Schmidlin, Eric ; Rouiller, Eric M.

In: Brain and Behavior, 2013, vol. 3, no. 5, p. 575–595

The present study aimed to determine and confront hand preference (hand chosen in priority to perform a manual dexterity task) and hand dominance (hand with best motor performance) in eight macaques (Macaca fascicularis) and in 20 human subjects (10 left-handers and 10 right-handers).Methods: Four manual dexterity tests have been executed by the monkeys, over several weeks during learning and...