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Inhibition of host NOX1 blocks tumor growth and enhances checkpoint inhibitor–based immunotherapy

Stalin, Jimmy ; Garrido-Urbani, Sarah ; Heitz, Freddy ; Szyndralewiez, Cédric ; Jemelin, Stephane ; Coquoz, Oriana ; Rüegg, Curzio ; Imhof, Beat A

In: Life Science Alliance, 2019, vol. 2, no. 4, p. -

Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade

Secondini, Chiara ; Coquoz, Oriana ; Spagnuolo, Lorenzo ; Spinetti, Thibaud ; Peyvandi, Sanam ; Ciarloni, Laura ; Botta, Francesca ; Bourquin, Carole ; Rüegg, Curzio

In: OncoImmunology, 2017, vol. 6, no. 6, p. e1316437

Tumor angiogenesis promotes tumor growth and metastasis. Anti-angiogenic therapy in combination with chemotherapy is used for the treatment of metastatic cancers, including breast cancer but therapeutic benefits are limited. Mobilization and accumulation of myeloid-derived suppressor cells (MDSC) during tumor progression and therapy have been implicated in metastasis formation and resistance to...