Université de Fribourg

Topology of the microsomal glycerol-3-phosphate acyltransferase Gpt2p/Gat1p of Saccharomyces cerevisiae

Pagac, Martin ; Vazquez, Hector M. ; Bochud, Arlette ; Roubaty, Carole ; Knöpfli, Cécile ; Vionnet, Christine ; Conzelmann, Andreas

In: Molecular Biology, 2012, p. -

All glycerophospholipids are made from phosphatidic acid, which, according to the traditional view, is generated at the cytosolic surface of the ER. In yeast, phosphatidic acid is synthesized de novo by two acyl-CoA dependent acylation reactions. The first is catalyzed by one of the two homologous glycerol-3-phosphate acyltransferases Gpt2p/Gat1p and Sct1p/Gat2p, the second by one of the two...