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Université de Fribourg

A hydrofluoric acid-free method to dissolve and quantify silica nanoparticles in aqueous and solid matrices

Bossert, David ; Urban, Dominic A. ; Maceroni, Mattia ; Ackermann-Hirschi, Liliane ; Haeni, Laetitia ; Yajan, Phattadon ; Spuch-Calvar, Miguel ; Rothen-Rutishauser, Barbara ; Rodriguez-Lorenzo, Laura ; Petri-Fink, Alke ; Schwab, Fabienne

In: Scientific Reports, 2019, vol. 9, no. 1, p. 7938

As the commercial use of synthetic amorphous silica nanomaterials (SiO2-NPs) increases, their effects on the environment and human health have still not been explored in detail. An often-insurmountable obstacle for SiO2-NP fate and hazard research is the challenging analytics of solid particulate silica species, which involves toxic and corrosive hydrofluoric acid (HF). We therefore developed...

Université de Fribourg

Magneto-responsive cell culture substrates that can be modulated in situ

Crippa, Federica ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 51–54

Understanding the interaction between cells and their environment is fundamental for mechanobiology. To mimic the behavior of cells in physiological and pathological conditions, synthetic substrates must have topographical and/or mechanical properties that evolve in time. Dynamic substrates mainly rely on stimuli-responsive materials where an external stimulus induces controlled variations in...

Université de Fribourg

A bio-inspired amplification cascade for the detection of rare cancer cells

Rüegg, Curzio ; Reis, Corine ; Rafiee, Sarah ; Rodriguez-Lorenzoa, Laura ; List, Jonathan ; Rothen-Rutishauser, Barbara ; Mayer, Michael ; Petri-Fink, Alke

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 63–68

The main cause of cancer-related death is due to cancer cell spreading and formation of secondary tumors in distant organs, the so-called metastases. Metastatic cancer cells are detectable in the blood of cancer patients as circulating tumor cells (CTC) and may be exploited for prognostic and monitoring purposes, including in breast cancer. Due to their very low frequency, however, their...

Université de Fribourg

Artificial lysosomal platform to study nanoparticle long-term stability

Milosevic, Ana ; Bourquin, Joël ; Burnand, David ; Lemal, Philipp ; Crippa, Federica ; Monnier, Christophe A. ; Rodriguez-Lorenzo, Laura ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 55–58

Nanoparticles (NPs) possess unique properties useful for designing specific functionalities for biomedi- cal applications. A prerequisite of a safe-by-design and effective use in any biomedical application is to study NP–cell interactions to gain a better understanding of cellular consequences upon exposure. Cellular uptake of NPs results mainly in the localization of NPs in the complex...

Université de Fribourg

An atomistic look into bio-inspired nanoparticles and their molecular interactions with cells

Petretto, Emanuele ; Campomanes, Pablo ; Stellacci, Francesco ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke ; Vanni, Stefano

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 78–80

Nanoparticles (NPs) have sizes that approach those of pathogens and they can interact with the membranes of eukaryotic cells in an analogous fashion. Typically, NPs are taken up by the cell via the plasma membrane by receptor-mediated processes and subsequently interact with various endomembranes. Unlike pathogens, however, NPs lack the remarkable specificity gained during the evolutionary...

Université de Fribourg

Heating behavior of magnetic iron oxide nanoparticles at clinically relevant concentration

Lemal, Philipp ; Balog, Sandor ; Geers, Christoph ; Taladriz-Blanco, Patricia ; Palumbo, Andrea ; M.Hirt, Ann ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Journal of Magnetism and Magnetic Materials, 2019, vol. 474, p. 637–642

Magnetic hyperthermia for cancer treatment has gained significant attention in recent years, due to its biocompatibility of applied nanoparticles and the possibility for spatially localized heating in deep tissues. Clinical treatments use nanoparticle concentrations of 112 mg Fe/mL, while the concentrations experimental studies have addressed are considerably smaller, usually between 0.1...

Université de Fribourg

Emergence of nanoplastic in the environment and possible impact on human health

Lehner, Roman ; Weder, Christoph ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Environmental Science & Technology, 2019, vol. 53, no. 4, p. 1748–1765

On account of environmental concerns, the fate and adverse effects of plastics have attracted considerable interest in the past few years. Recent studies have indicated the potential for fragmentation of plastic materials into nanoparticles, i.e., “nanoplastics,” and their possible accumulation in the environment. Nanoparticles can show markedly different chemical and physical properties...

Université de Fribourg

Nanoparticle administration method in cell culture alters particle-cell interaction

Moore, Thomas L. ; Urban, Dominic A. ; Rodriguez-Lorenzo, Laura ; Milosevic, Ana ; Crippa, Federica ; Spuch-Calvar, Miguel ; Balog, Sandor ; Rothen-Rutishauser, Barbara ; Lattuada, Marco ; Petri-Fink, Alke

In: Scientific Reports, 2019, vol. 9, no. 1, p. 900

As a highly interdisciplinary field, working with nanoparticles in a biomedical context requires a robust understanding of soft matter physics, colloidal behaviors, nano- characterization methods, biology, and bio-nano interactions. When reporting results, it can be easy to overlook simple, seemingly trivial experimental details. In this context, we set out to understand how in vitro...

Université de Fribourg

Nanoparticles and Taylor dispersion as a linear time-invariant system

Lemal, Philipp ; Petri-Fink, Alke ; Balog, Sandor

In: Analytical Chemistry, 2019, vol. 91, no. 2, p. 1217–1221

The physical principles underpinning Taylor dispersion offer a high dynamic range to characterize the hydrodynamic radius of particles. While Taylor dispersion grants the ability to measure radius within nearly 5 orders of magnitude, the detection of particles is never instantaneous. It requires a finite sample volume, a finite detector area, and a finite detection time for measuring...