In: Psychopharmacology, 2015, vol. 232, no. 12, p. 2097-2112
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In: eNeuro, 2018, vol. 5, no. 4, p. -
Our understanding of the neurobiological underpinnings of learning and behavior relies on the use of invasive techniques, which necessitate the use of animal models. However, when different species learn the same task, to what degree are they actually producing the same behavior and engaging homologous neural circuitry? This question has received virtually no recent attention, even as the...
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In: Cell Reports, 2018, vol. 23, no. 8, p. 2405–2415
Despite well-known privileged perception of dark over light stimuli, it is unknown to what extent this dark dominance is maintained when visual transients occur in rapid succession, for example, during perception of moving stimuli. Here, we address this question using dark and light transients presented at different flicker frequencies. Although both human participants and tree shrews...
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In: Analytical Chemistry, 2015, vol. 87, no. 23, p. 11646–11651
The main goal of the present study is to develop a method to recognize and identify endogenous intrachain disulfide bonded peptide, which are rarely sequenced in current peptidomics studies. In order to achieve highly efficient detection of these peptides in a neuropeptidome analysis, we alkylated the peptides, mined the raw mass spectrometry data, and then recognized the candidates of untreated...
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In: Psychopharmacology, 2015, vol. 232, no. 12, p. 2097–2112
Despite the evidence for altered decision making in cannabis abusers, the role of the cannabinoid system in decision-making circuits has not been studied. Here, we examined the effects of cannabinoid modulation during cost-benefit decision making in the anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC), key brain areas involved in decision making. We trained different groups of...
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In: Journal of Neurophysiology, 2014, vol. 111, no. 9, p. 1717–1720
Recently, the functional specialization of prefrontal areas of the brain, and, specifically, the functional dissociation of the orbitofrontal cortex (OFC) and the anterior cingulate cortex (ACC), during decision making have become a particular focus of research. A number of neuropsychological and lesion studies have shown that the OFC and ACC have dissociable functions in various dimensions of...
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In: Frontiers in Psychology - Cognitive Science, 2014, vol. 5, p. 303
Novelty preference is pervasive in mammalian species, and describes an inherent tendency to preferentially explore novelty. The novel location memory task studied here assesses the ability of animals to form accurate memories of a spatial configuration, consisting of several identical objects placed within an arena. Tree shrews were first familiarized with a particular object configuration during...
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In: Behavioural Processes, 2012, vol. 90, no. 3, p. 364–371
Recognition memories are formed during perceptual experience and allow subsequent recognition of previously encountered objects as well as their distinction from novel objects. As a consequence, novel objects are generally explored longer than familiar objects by many species. This novelty preference has been documented in rodents using the novel object recognition (NOR) test, as well is in...
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