Université de Fribourg

Spatial SPION localization in liposome membranes

Bonnaud, Cécile ; Vanhecke, Dimitri ; Demurtas, Davide ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: IEEE Transactions on Magnetics, 2012, vol. 49, no. 1, p. 166-171

Nanocarriers, including liposomes, offer great opportunities for targeted and controlled therapy. The development in this field has led to a large panel of drug delivery systems, which can be classified into 3 different nanovector generations. However, the success of such smart materials requires the control of a large variety of properties and parameters. Unfortunately, characterization at the...

Université de Fribourg

Improved dynamic response assessment for intra-articular injected iron oxide nanoparticles

Crowe, L. A. ; Tobalem, F. ; Gramoun, A. ; Delattre, B. M. A. ; Grosdemange, K. ; Salaklang, Jatuporn ; Redjem, A. ; Petri-Fink, Alke ; Hofmann, Heinrich ; Vallée, J.-P.

In: Magnetic Resonance in Medicine, 2012, vol. 68, no. 5, p. 1544–1552

The emerging importance of nanoparticle technology, including iron oxide nanoparticles for monitoring development, progression, and treatment of inflammatory diseases such as arthritis, drives development of imaging techniques. Studies require an imaging protocol that is sensitive and quantifiable for the detection of iron oxide over a wide range of concentrations. Conventional signal loss...