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Dietary spermidine for lowering high blood pressure

Eisenberg, Tobias ; Abdellatif, Mahmoud ; Zimmermann, Andreas ; Schroeder, Sabrina ; Pendl, Tobias ; Harger, Alexandra ; Stekovic, Slaven ; Schipke, Julia ; Magnes, Christoph ; Schmidt, Albrecht ; Ruckenstuhl, Christoph ; Dammbrueck, Christopher ; Gross, Angelina S. ; Herbst, Viktoria ; Carmona-Gutierrez, Didac ; Pietrocola, Federico ; Pieber, Thomas R. ; Sigrist, Stephan J. ; Linke, Wolfgang A. ; Mühlfeld, Christian ; Sadoshima, Junichi ; Dengjel, Jörn ; Kiechl, Stefan ; Kroemer, Guido ; Sedej, Simon ; Madeo, Frank

In: Autophagy, 2017, vol. 13, no. 4, p. 767-769

Loss of cardiac macroautophagy/autophagy impairs heart function, and evidence accumulates that an increased autophagic flux may protect against cardiovascular disease. We therefore tested the protective capacity of the natural autophagy inducer spermidine in animal models of aging and hypertension, which both represent major risk factors for the development of cardiovascular disease. Dietary...