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Neuroendocrine characterization and anorexigenic effects of telmisartan in diet- and glitazone-induced weight gain

Aubert, Gregory ; Burnier, Michel ; Dulloo, Abdul G. ; Perregaux, Christine ; Mazzolai, Lucia ; Pralong, François ; Zanchi, Anne

In: Metabolism - Clinical and Experimental, 2010, vol. 59, no. 1, p. 25-32

Telmisartan is an angiotensin II receptor blocker with peroxisome proliferator–activated receptor–γ agonistic properties. Telmisartan prevents weight gain and decreases food intake in models of obesity and in glitazone-treated rodents. This study further investigates the influence of telmisartan and pioglitazone and their association on weight gain and body composition by examining...