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Notch1 activity in the olfactory bulb is odour-dependent and contributes to olfactory behaviour

Brai, Emanuele ; Marathe, Swananda ; Zentilin, Lorena ; Giacca, Mauro ; Nimpf, Johannes ; Kretz, Robert ; Scotti, Alessandra ; Alberi, Lavinia

In: European Journal of Neuroscience, 2014, vol. 40, no. 10, p. 3436–3449

Notch signalling plays an important role in synaptic plasticity, learning and memory functions in both Drosophila and rodents. In this paper, we report that this feature is not restricted to hippocampal networks but also involves the olfactory bulb (OB). Odour discrimination and olfactory learning in rodents are essential for survival. Notch1 expression is enriched in mitral cells of the mouse...