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Notch1 regulates hippocampal plasticity through interaction with the reelin pathway, glutamatergic transmission and CREB signaling

Brai, Emanuele ; Marathe, Swananda ; Astori, Simone ; Fredj, Naila Ben ; Perry, Elisabeth ; Lamy, Christophe ; Scotti, Alessandra ; Alberi, Lavinia

In: Frontiers in Cellular Neuroscience, 2015, p. 447

Notch signaling plays a crucial role in adult brain function such as synaptic plasticity, memory and olfaction. Several reports suggest an involvement of this pathway in neurodegenerative dementia. Yet, to date, the mechanism underlying Notch activity in mature neurons remains unresolved. In this work, we investigate how Notch regulates synaptic potentiation and contributes to the establishment...