Université de Fribourg

Notch1 regulates hippocampal plasticity through interaction with the reelin pathway, glutamatergic transmission and CREB signaling

Brai, Emanuele ; Marathe, Swananda ; Astori, Simone ; Fredj, Naila Ben ; Perry, Elisabeth ; Lamy, Christophe ; Scotti, Alessandra ; Alberi, Lavinia

In: Frontiers in Cellular Neuroscience, 2015, p. 447

Notch signaling plays a crucial role in adult brain function such as synaptic plasticity, memory and olfaction. Several reports suggest an involvement of this pathway in neurodegenerative dementia. Yet, to date, the mechanism underlying Notch activity in mature neurons remains unresolved. In this work, we investigate how Notch regulates synaptic potentiation and contributes to the establishment...

Université de Fribourg

Notch1 activity in the olfactory bulb is odour-dependent and contributes to olfactory behaviour

Brai, Emanuele ; Marathe, Swananda ; Zentilin, Lorena ; Giacca, Mauro ; Nimpf, Johannes ; Kretz, Robert ; Scotti, Alessandra ; Alberi, Lavinia

In: European Journal of Neuroscience, 2014, vol. 40, no. 10, p. 3436–3449

Notch signalling plays an important role in synaptic plasticity, learning and memory functions in both Drosophila and rodents. In this paper, we report that this feature is not restricted to hippocampal networks but also involves the olfactory bulb (OB). Odour discrimination and olfactory learning in rodents are essential for survival. Notch1 expression is enriched in mitral cells of the mouse...

Université de Fribourg

Notch signaling in the brain: In good and bad times

Alberi, Lavinia ; Hoey, Sarah ; Brai, Emanuele ; Scotti, Alessandra ; Marathe, Swananda

In: Ageing Research Reviews, 2013, p. -

Notch signaling is an evolutionarily conserved pathway, which is fundamental for neuronal development and specification. In the last decade, increasing evidence has pointed out an important role of this pathway beyond embryonic development, indicating that Notch also displays a critical function in the mature brain of vertebrates and invertebrates. This pathway appears to be involved in neural...