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Match-making for posaconazole through systems thinking

Fügi, Matthias A. ; Kaiser, Marcel ; Tanner, Marcel ; Schneiter, Roger ; Mäser, Pascal ; Guan, Xue Li

In: Trends in Parasitology, 2015, vol. 31, no. 2, p. 46–51

Currently available drugs for Chagas’ disease are limited by toxicity and low efficacy in the chronic stage. Posaconazole, the most advanced new anti-chagasic drug candidate, did not fully confirm its initial potential in a Phase II clinical trial for chronic Chagas’ disease. Given that posaconazole is highly active against Trypanosoma cruzi in vitro, and was very well tolerated in clinical...