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Dopamine deficiency increases synchronized activity in the rat subthalamic nucleus

Lintas, Alessandra ; Silkis, Isabella G. ; Albéri, Lavinia ; Villa, Alessandro E.P.

In: Brain Research, 2012, vol. 1434, p. 142–151

Abnormal neuronal activity in the subthalamic nucleus (STN) plays a crucial role in the pathophysiology of Parkinson's disease (PD). In this study we investigated changes in rat STN neuronal activity after 28 days following the injection of 6-OHDA in the substantia nigra pars compacta (SNc). This drug provoked a lesion of SNc that induced a dopamine (DA) depletion assessed by changes in rotating...