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Angiogenic activity of breast cancer patients’ monocytes reverted by combined use of systems modeling and experimental approaches

Guex, Nicolas ; Crespo, Isaac ; Bron, Sylvian ; Ifticene-Treboux, Assia ; Faes-van’t Hull, Eveline ; Kharoubi, Solange ; Liechti, Robin ; Werffeli, Patricia ; Ibberson, Mark ; Majo, Francois ; Nicolas, Michäel ; Laurent, Julien ; Garg, Abhishek ; Lehr, Khalil Zaman,Hans-Anton ; Stevenson, Brian J. ; Rüegg, Curzio ; Coukos, George ; Delaloye, Jean-François ; Xenarios, Ioannis ; Doucey, Marie-Agnès

In: PLoS Comput Biol, 2015, vol. 11, no. 3, p. e1004050

Angiogenesis plays a key role in tumor growth and cancer progression. TIE-2-expressing monocytes (TEM) have been reported to critically account for tumor vascularization and growth in mouse tumor experimental models, but the molecular basis of their pro-angiogenic activity are largely unknown. Moreover, differences in the pro-angiogenic activity between blood circulating and tumor infiltrated TEM...