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LIN-39 and the EGFR/RAS/MAPK pathway regulate C. elegans vulval morphogenesis via the VAB-23 zinc finger protein

Pellegrino, Mark W. ; Farooqui, Sarfarazhussain ; Fröhli, Erika ; Rehrauer, Hubert ; Kaeser-Pebernard, Stéphanie ; Müller, Fritz ; Gasser, Robin B. ; Hajnal, Alex

In: Development, 2011, vol. 138, no. 4649-4660, p. -

Morphogenesis represents a phase of development during which cell fates are executed. The conserved hox genes are key cell fate determinants during metazoan development, but their role in controlling organ morphogenesis is less understood. Here, we show that the C. elegans hox gene lin-39 regulates epidermal morphogenesis via its novel target, the essential zinc finger protein VAB-23. During the...