In: Journal of Cellular and Molecular Medicine, 2018, p. -
Vascular Endothelial Growth Factor (VEGF) can induce normal or aberrant angiogenesis depending on the amount secreted in the microenvironment around each cell. Towards a possible clinical translation, we developed a Fluorescence Activated Cell Sorting (FACS)‐based technique to rapidly purify transduced progenitors that homogeneously express a desired specific VEGF level from heterogeneous...
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In: Experimental Physiology, 2018, vol. 103, no. 1, p. 1–8
Given the importance of peripheral blood haematopoietic stem and progenitor cells (HPCs) in post-acute regeneration after acute myocardial infarction (MI), the aim of the present study was to investigate the number and secondary replating capacity/self-renewal ability of HPCs in peripheral blood before and 2 weeks after MI. In female Lewis inbred rats (n = 9), MI was induced by ligation of...
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In: Cardiovascular Therapeutics, 2017, vol. 35, no. 2, p. -
Acute coronary syndrome is a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerable atherosclerotic plaque with secondary platelet activation and thrombus formation, which leads to partial or complete luminal obstruction...
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In: Frontiers in Physiology - Clinical and Translational Physiology, 2015, vol. 6, p. 353
Coronary artery ligations to induce myocardial infarction (MI) in mice and rats are widely used in preclinical investigation. However, myocardial ischemic damage and subsequent infarct size are highly variable. The lack of standardization of the model impairs the probability of effective translation to the clinic. Cardiac Troponin I (cTnI) is a major clinically relevant biomarker.Aim: In the...
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In: Surface and Coatings Technology, 2014, vol. 255, p. 90–95
Materials for biomedical applications typically involve surface engineering. Scaffolds used for tissue engineering, for example, require a surface functionalization in order to support cell growth. The deposition of functional plasma polymer coatings seems to be an attractive approach to modify substrates for biomedical applications.Possible degradation of highly functional plasma polymers and...
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In: Biomedical Materials, 2013, vol. 8, no. 2, p. 021001
Engineered muscle constructs provide a promising perspective on the regeneration or substitution of irreversibly damaged skeletal muscle. However, the highly ordered structure of native muscle tissue necessitates special consideration during scaffold development. Multiple approaches to the design of anisotropically structured substrates with grooved micropatterns or parallel-aligned fibres have...
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