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A multi-layered quantitative in vivo expression atlas of the podocyte unravels kidney disease candidate genes

Rinschen, Markus M. ; Gödel, Markus ; Grahammer, Florian ; Zschiedrich, Stefan ; Helmstädter, Martin ; Kretz, Oliver ; Zarei, Mostafa ; Braun, Daniela A. ; Dittrich, Sebastian ; Pahmeyer, Caroline ; Schroder, Patricia ; Teetzen, Carolin ; Gee, HeonYung ; Daouk, Ghaleb ; Pohl, Martin ; Kuhn, Elisa ; Schermer, Bernhard ; Küttner, Victoria ; Boerries, Melanie ; Busch, Hauke ; Schiffer, Mario ; Bergmann, Carsten ; Krüger, Marcus ; Hildebrandt, Friedhelm ; Dengjel, Jörn ; Benzing, Thomas ; Huber, Tobias B.

In: Cell Reports, 2018, vol. 23, no. 8, p. 2495–2508

Damage to and loss of glomerular podocytes has been identified as the culprit lesion in progressive kidney diseases. Here, we combine mass spectrometry-based proteomics with mRNA sequencing, bioinformatics, and hypothesis-driven studies to provide a comprehensive and quantitative map of mammalian podocytes that identifies unanticipated signaling pathways. Comparison of the in vivo datasets...