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The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier

Schell, Christoph ; Rogg, Manuel ; Suhm, Martina ; Helmstädter, Martin ; Sellung, Dominik ; Yasuda-Yamahara, Mako ; Kretz, Oliver ; Küttner, Victoria ; Suleiman, Hani ; Kollipara, Laxmikanth ; Zahedi, René P. ; Sickmann, Albert ; Eimer, Stefan ; Shaw, Andrey S. ; Kramer-Zucker, Albrecht ; Hirano-Kobayashi, Mariko ; Abe, Takaya ; Aizawa, Shinichi ; Grahammer, Florian ; Hartleben, Björn ; Dengjel, Jörn ; Huber, Tobias B.

In: Proceedings of the National Academy of Sciences, 2017, vol. 114, no. 23, p. E4621–E4630

Podocytes form the outer part of the glomerular filter, where they have to withstand enormous transcapillary filtration forces driving glomerular filtration. Detachment of podocytes from the glomerular basement membrane precedes most glomerular diseases. However, little is known about the regulation of podocyte adhesion in vivo. Thus, we systematically screened for podocyte-specific focal...