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Metabolic and glucostatic control of feeding

Langhans, Wolfgang

In: Proceedings of the Nutrition Society, 1996, vol. 55, no. 1B, p. 497-515

Université de Fribourg

In vivo over-expression of interleukin-10 increases resistance to focal brain ischemia in mice

Bilbao, Fabienne de ; Arsenijevic, Denis ; Moll, Thomas ; Garcia-Gabay, Irene ; Vallet, Philippe ; Langhans, Wolfgang ; Giannakopoulos, Panteleimon

In: Journal of Neurochemistry, 2009///doi: 10.1111/j.1471-4159.2009.06098.x

Early studies showed that the administration of the anti-inflammatory cytokine interleukin-10 (IL10) protects against permanent middle cerebral artery occlusion (MCAO) in mice. In this study, transgenic mice expressing murine IL10 (IL10T) directed by the major histocompatibility complex Ea promoter were produced and used to explore the effect of chronically increased IL10 levels on MCAO-related...

Université de Fribourg

Decreased infarct size after focal cerebral ischemia in mice chronically infected with Toxoplasma gondii

Arsenijevic, Denis ; Bilbao, F. de ; Vallet, Philippe ; Hemphill, Andrew ; Gottstein, B. ; Richard, Denis ; Giannakopoulos, Panteleimon ; Langhans, Wolfgang

In: Neuroscience, 2007, vol. 150, no. 3, p. 537-546

To determine whether Toxoplasma gondii infection could modify biological phenomena associated with brain ischemia, we investigated the effect of permanent middle cerebral artery occlusion (MCAO) on neuronal survival, inflammation and redox state in chronically infected mice. Infected animals showed a 40% to 50% decrease of infarct size compared with non-infected littermates 1, 4 and 14 days after...

Université de Fribourg

Role for glutathione in the hyposensitivity of LPS-pretreated mice to LPS anorexia

Hernadfalvi, Noemi ; Langhans, Wolfgang ; Meyenburg, Claudia von ; Onteniente, Brigitte ; Richard, Denis ; Arsenijevic, Denis

In: European Cytokine Network, 2007, vol. 18, no. 2, p. 39-45

To study the role of the redox state regulator glutathione (GSH) in bacterial lipopolysaccharide (LPS)-induced anorexia we measured GSH in liver, serum and brain in response to intraperitoneal (ip) lipopolysaccharide (LPS, 4μg/mouse) injection in LPS-naïve and LPS-pretreated (4 μg/mouse) mice. LPS reduced food intake in LPS-naïve mice and LPS pretreatment attenuated this effect. LPS...