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    Université de Fribourg

    Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism

    Garrido-Urbani, Sarah ; Jemelin, Stephane ; Deffert, Christine ; Carnesecchi, Stéphanie ; Basset, Olivier ; Szyndralewiez, Cédric ; Heitz, Freddy ; Page, Patrick ; Montet, Xavier ; Michalik, Liliane ; Arbiser, Jack ; Rüegg, Curzio ; Krause, Karl Heinz ; Imhof, Beat A.

    In: PLoS ONE, 2011, vol. 6, no. 2, p. e14665

    Reactive oxygen species, ROS, are regulators of endothelial cell migration, proliferation and survival, events critically involved in angiogenesis. Different isoforms of ROS-generating NOX enzymes are expressed in the vasculature and provide distinct signaling cues through differential localization and activation. We show that mice deficient in NOX1, but not NOX2 or NOX4, have impaired...