Université de Fribourg

Mood effects after deep brain stimulation for Parkinson’s disease: an update

Accolla, Ettore A. ; Pollo, Claudio

In: Frontiers in Neurology, 2019, vol. 10, p. 617

Depression in Parkinson's Disease (PD) is a prevalent and invalidating symptom. Deep brain stimulation (DBS) allows for an improvement of PD motor features, but its effects on mood are difficult to predict. Here, we review the evidence regarding mood effects after DBS of either subthalamic nucleus (STN) or globus pallidus pars interna (GPi). Different influences of multiple factors contribute...

Université de Fribourg

Brain networks modulated by subthalamic nucleus deep brain stimulation

Accolla, Ettore A. ; Ruiz, Maria Herrojo ; Horn, Andreas ; Schneider, Gerd-Helge ; Schmitz-Hübsch, Tanja ; Draganski, Bogdan ; Kühn, Andrea A.

In: Brain, 2016, vol. 139, no. 9, p. 2503–2515

Deep brain stimulation of the subthalamic nucleus is an established treatment for the motor symptoms of Parkinson’s disease. Given the frequent occurrence of stimulation- induced affective and cognitive adverse effects, a better understanding about the role of the subthalamic nucleus in non-motor functions is needed. The main goal of this study is to characterize anatomical circuits...