Université de Fribourg

4,4’Dimethoxychalcone: a natural flavonoid that promotes health through autophagy-dependent and -independent effects

Zimmermann, Andreas ; Kainz, Katharina ; Hofer, Sebastian J. ; Bauer, Maria A. ; Schroeder, Sabrina ; Dengjel, Jörn ; Pietrocola, Federico ; Kepp, Oliver ; Ruckenstuhl, Christoph ; Eisenberg, Tobias ; Sigrist, Stephan J. ; Madeo, Frank ; Carmona-Gutierrez, Didac ; Kroemer, Guido

In: Autophagy, 2019, vol. 15, no. 9, p. 1662–1664

The age-induced deterioration of the organism results in detrimental and ultimately lethal pathologies. The process of aging itself involves a plethora of different mechanisms that should be subverted concurrently to delay and/or prevent age- related maladies. We have identified a natural compound, 4,4ʹ-dimethoxychalcone (DMC), which promotes longevity in yeast, worms and flies, and protects...

Université de Fribourg

Targeting GATA transcription factors – a novel strategy for anti-aging interventions?

Zimmermann, Andreas ; Kainz, Katharina ; Hofer, Sebastian J. ; Bauer, Maria A. ; Schroeder, Sabrina ; Dengjel, Jörn ; Pietrocola, Federico ; Kepp, Oliver ; Ruckenstuhl, Christoph ; Eisenberg, Tobias ; Sigrist, Stephan J. ; Madeo, Frank ; Kroemer, Guido ; Carmona-Gutierrez, Didac

In: Microbial Cell, 2019, vol. 6, no. 5, p. 212–216

GATA transcription factors (TFs) constitute a conserved family of zinc-finger TFs that fulfill diverse functions across eukaryotes. Accumulating evidence suggests that GATA TFs also play a role in lifespan regulation. In a recent study, we identified a natural polyphenol, 4,4’-dimethoxychalcone (DMC), that extends lifespan depending on reduced activity of distinct GATA TFs. Prolonged...

Université de Fribourg

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

Carmona-Gutierrez, Didac ; Zimmermann, Andreas ; Kainz, Katharina ; Pietrocola, Federico ; Chen, Guo ; Maglioni, Silvia ; Schiavi, Alfonso ; Nah, Jihoon ; Mertel, Sara ; Beuschel, Christine B. ; Castoldi, Francesca ; Sica, Valentina ; Trausinger, Gert ; Raml, Reingard ; Sommer, Cornelia ; Schroeder, Sabrina ; Hofer, Sebastian J. ; Bauer, Maria A. ; Pendl, Tobias ; Tadic, Jelena ; Dammbrueck, Christopher ; Hu, Zehan ; Ruckenstuhl, Christoph ; Eisenberg, Tobias ; Durand, Sylvere ; Bossut, Noélie ; Aprahamian, Fanny ; Abdellatif, Mahmoud ; Sedej, Simon ; Enot, David P. ; Wolinski, Heimo ; Dengjel, Jörn ; Kepp, Oliver ; Magnes, Christoph ; Sinner, Frank ; Pieber, Thomas R. ; Sadoshima, Junichi ; Ventura, Natascia ; Sigrist, Stephan J. ; Kroemer, Guido ; Madeo, Frank

In: Nature Communications, 2019, vol. 10, no. 1, p. 651

Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural and pharmacological interventions with feasible potential to promote health upon ageing remain rare. Here we report the identification of the flavonoid 4,4′- dimethoxychalcone (DMC) as a natural compound with anti-ageing...

Université de Fribourg

Dietary spermidine for lowering high blood pressure

Eisenberg, Tobias ; Abdellatif, Mahmoud ; Zimmermann, Andreas ; Schroeder, Sabrina ; Pendl, Tobias ; Harger, Alexandra ; Stekovic, Slaven ; Schipke, Julia ; Magnes, Christoph ; Schmidt, Albrecht ; Ruckenstuhl, Christoph ; Dammbrueck, Christopher ; Gross, Angelina S. ; Herbst, Viktoria ; Carmona-Gutierrez, Didac ; Pietrocola, Federico ; Pieber, Thomas R. ; Sigrist, Stephan J. ; Linke, Wolfgang A. ; Mühlfeld, Christian ; Sadoshima, Junichi ; Dengjel, Joern ; Kiechl, Stefan ; Kroemer, Guido ; Sedej, Simon ; Madeo, Frank

In: Autophagy, 2017, vol. 0, no. 0, p. 1–3

Loss of cardiac macroautophagy/autophagy impairs heart function, and evidence accumulates that an increased autophagic flux may protect against cardiovascular disease. We therefore tested the protective capacity of the natural autophagy inducer spermidine in animal models of aging and hypertension, which both represent major risk factors for the development of cardiovascular disease. Dietary...