Université de Fribourg

Myocardial infarction stabilization by cell-based expression of controlled Vascular Endothelial Growth Factor levels

Melly, Ludovic ; Cerino, Giulia ; Frobert, Aurélien ; Cook, Stéphane ; Giraud, Marie-Noëlle ; Carrel, Thierry ; Tevaearai Stahel, Hendrik T. ; Eckstein, Friedrich ; Rondelet, Benoît ; Marsano, Anna ; Banfi, Andrea

In: Journal of Cellular and Molecular Medicine, 2018, p. -

Vascular Endothelial Growth Factor (VEGF) can induce normal or aberrant angiogenesis depending on the amount secreted in the microenvironment around each cell. Towards a possible clinical translation, we developed a Fluorescence Activated Cell Sorting (FACS)‐based technique to rapidly purify transduced progenitors that homogeneously express a desired specific VEGF level from heterogeneous...

Université de Fribourg

Heart rate never lies: interventional cardiologist and Braude’s quote revised

Cook, Stéphane ; Stauffer, Jean-Christophe ; Goy, Jean-Jacques ; Graf, Denis ; Puricel, Serban ; Frobert, Aurélien ; Muller, Olivier ; Togni, Mario ; Arroyo, Diego

In: Open Heart, 2016, vol. 3, no. 1, p. e000373

Background Interventional cardiologists may be immune to stress, allowing them to perform complex percutaneous interventions under pressure.Objectives To assess heart rate (HR) variations as a surrogate marker of stress of interventional cardiologists during percutaneous cardiac procedures and in every-day life.Design This is a single-centre...

Université de Fribourg

Prognostic value of troponin I for infarct size to improve preclinical myocardial infarction small animal models

Frobert, Aurélien ; Valentin, Jérémy ; Magnin, Jean-Luc ; Riedo, Erwin ; Cook, Stéphane ; Giraud, Marie-Noëlle

In: Frontiers in Physiology - Clinical and Translational Physiology, 2015, vol. 6, p. 353

Coronary artery ligations to induce myocardial infarction (MI) in mice and rats are widely used in preclinical investigation. However, myocardial ischemic damage and subsequent infarct size are highly variable. The lack of standardization of the model impairs the probability of effective translation to the clinic. Cardiac Troponin I (cTnI) is a major clinically relevant biomarker.Aim: In the...