Université de Fribourg

Molecular Pathways: Emerging pathways mediating growth, invasion and metastasis of tumors progressing in an irradiated microenvironment

Kuonen, Francois ; Secondini, Chiara ; Ruegg, Curzio

In: Clinical Cancer Research, 2012, p. -

Radiotherapy is a well-established therapeutic modality in oncology. It provides survival benefits in several different cancer types. However, cancers relapsing after radiotherapy often develop into more aggressive conditions, which are difficult to treat and are associated with poor prognosis. Cumulating experimental evidence indicates that the irradiated tumor bed contributes to such aggressive...

Université de Fribourg

Inhibition of the Kit ligand/c-Kit axis attenuates metastasis in a mouse model mimicking local breast cancer relapse after radiotherapy

Kuonen, Francois ; Laurent, Jullien ; Secondini, Chiara ; Lorusso, Girieca ; Stehle, Jean-Christophe ; Rausch, Thierry ; Hull, Eveline Faes-van't ; Bieler, Gregory ; Alghisi, Gian Carlo ; Schwendener, Reto A. ; Andrejevic-Blant, Snezana ; Mirimanoff, René-Olivier ; Ruegg, Curzio

In: Clinical Cancer Research, 2012, p. -

Purpose: Local breast cancer relapse after breast-saving surgery and radiotherapy is associated with increased risk of distant metastasis formation. The mechanisms involved remain largely elusive. We used the well-characterized 4T1 syngeneic, orthotopic breast cancer model to identify novel mechanisms of post-radiation metastasis. Experimental Design: 4T1 cells were injected in 20 Gy...

Université de Fribourg

Proangiogenic factor PlGF programs CD11b+ myelomonocytes in breast cancer during differentiation of their hematopoietic progenitors

Laurent, Julien ; Faes-van't Hull, Eveline ; Touvrey, Cedric ; Kuonen, Francois ; Lan, Qiang ; Lorusso, Girieca ; Doucey, Marie-Agnes ; Ciarloni, Laura ; Imaizumi, Natsuko ; Alghisi, Gian Carlo ; Fagiani, Ernesta ; Zaman, Khalil ; Stupp, Roger ; Shibuya, Masabumi ; Delaloye, Jean-François ; Christofori, Gerhard ; Ruegg, Curzio

In: Cancer Research, 2011, p. -

Tumor-mobilized bone marrow-derived CD11b+ myeloid cells promote tumor angiogenesis, but how and when these cells acquire proangiogenic properties is not fully elucidated. Here we show that CD11b+ myelomonocytic cells develop proangiogenic properties during their differentiation from CD34+ hematopoietic progenitors and that Placenta Growth Factor (PlGF) is critical in promoting this education....