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Receptor-targeted lentiviral vectors are exceptionally sensitive toward the biophysical properties of the displayed single-chain Fv

Friedel, Thorsten ; Hanisch, Lydia J. ; Muth, Anke ; Honegger, Annemarie ; Abken, Hinrich ; Plückthun, Andreas ; Buchholz, Christian J. ; Schneider, Irene C.

In: Protein Engineering, Design & Selection, 2015, vol. 28, no. 4, p. 93-106

Selective Bispecific T Cell Recruiting Antibody and Antitumor Activity of Adoptive T Cell Transfer

Kobold, Sebastian ; Steffen, Julius ; Chaloupka, Michael ; Grassmann, Simon ; Henkel, Jonas ; Castoldi, Raffaella ; Zeng, Yi ; Chmielewski, Markus ; Schmollinger, Jan C. ; Schnurr, Max ; Rothenfußer, Simon ; Schendel, Dolores J. ; Abken, Hinrich ; Sustmann, Claudio ; Niederfellner, Gerhard ; Klein, Christian ; Bourquin, Carole ; Endres, Stefan

In: Journal Of The National Cancer Institute, 2014, vol. 107, no. 1, p. -

Selective bispecific T cell recruiting antibody and antitumor activity of adoptive T cell transfer

Kobold, Sebastian ; Steffen, Julius ; Chaloupka, Michael ; Grassmann, Simon ; Henkel, Jonas ; Castoldi, Raffaella ; Zeng, Yi ; Chmielewski, Markus ; Schmollinger, Jan C. ; Schnurr, Max ; Rothenfußer, Simon ; Schendel, Dolores J. ; Abken, Hinrich ; Sustmann, Claudio ; Niederfellner, Gerhard ; Klein, Christian ; Bourquin, Carole ; Endres, Stefan

In: Journal of the National Cancer Institute, 2014, vol. 107, no. 1, p. dju364

Background: One bottleneck for adoptive T cell therapy (ACT) is recruitment of T cells into tumors. We hypothesized that combining tumor-specific T cells, modified with a marker antigen and a bispecific antibody (BiAb) that selectively recognizes transduced T cells and tumor cells would improve T cell recruitment to tumors and enhance therapeutic efficacy.Methods: SV40 T antigen–specific T...