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Université de Fribourg

Polymer-coated gold nanospheres do not impair the innate immune function of human b lymphocytes in vitro

Hočevar, Sandra ; Milošević, Ana ; Rodriguez-Lorenzo, Laura ; Ackermann-Hirschi, Liliane ; Mottas, Ines ; Petri-Fink, 6 Alke ; Rothen-Rutishauser, Barbara ; Bourquin, Carole ; Clift, Martin James David

In: ACS Nano, 2019, vol. 13, no. 6, p. 6790–6800

Gold nanoparticles (GNPs) are intended for use within a variety of biomedical applications due to their physicochemical properties. Although, in general, biocompatibility of GNPs with immune cells such as macrophages and dendritic cells is well established, the impact of GNPs on B lymphocyte immune function remains to be determined. Since B lymphocytes play an important role in health and...

Université de Fribourg

Development of resiquimod-loaded modified PLA-based nanoparticles for cancer immunotherapy: A kinetic study

Thauvin, Cédric ; Widmer, Jérôme ; Mottas, Inès ; Hocevar, Sandra ; Allémann, Eric ; Bourquin, Carole ; Delie, Florence

In: European Journal of Pharmaceutics and Biopharmaceutics, 2019, vol. 139, p. 253–261

Resiquimod (R848), a member of the imidazoquinoline family, is a Toll-like receptor 7/8 agonist with high potency for cancer immunotherapy. However, tolerance induction and adverse effects limit its development as a drug. Encapsulation in a polymer matrix can circumvent these limitations, as shown in our formerly published approach where R848 was loaded into polylactic acid (PLA)-based...

Université de Fribourg

Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation

Mottas, Inès ; Bekdemir, Ahmet ; Cereghetti, Alessandra ; Spagnuolo, Lorenzo ; Yang, Yu-Sang Sabrina ; Müller, Marie ; J.Irvine, Darrell ; Stellaccic, Francesco ; Bourquin, Carole

In: Biomaterials, 2019, vol. 190–191, p. 111–120

Although immunotherapy shows great promise for the long-term control of cancer, many tumors still fail to respond to treatment. To improve the outcome, the delivery of immunostimulants to the lymph nodes draining the tumor, where the antitumor immune response is initiated, is key. Efforts to use nanoparticles as carriers for cancer immunotherapy have generally required targeting agents and...

Université de Fribourg

Hook length of the bacterial flagellum is optimized for maximal stability of the flagellar bundle

Spöring, Imke ; Martinez, Vincent A. ; Hotz, Christian ; Schwarz-Linek, Jana ; Grady, Keara L. ; Nava-Sedeño, Josué M. ; Vissers, Teun ; Singer, Hanna M. ; Rohde, Manfred ; Bourquin, Carole ; Hatzikirou, Haralampos ; Poon, Wilson C. K. ; Dufour, Yann S. ; Erhardt, Marc

In: PLOS Biology, 2018, vol. 16, no. 9, p. e2006989

Most bacteria swim in liquid environments by rotating one or several flagella. The long external filament of the flagellum is connected to a membrane-embedded basal body by a flexible universal joint, the hook, which allows the transmission of motor torque to the filament. The length of the hook is controlled on a nanometer scale by a sophisticated molecular ruler mechanism. However, why its...

Université de Fribourg

Engineered hybrid spider silk particles as delivery system for peptide vaccines

Lucke, Matthias ; Mottas, Inès ; Herbst, Tina ; Hotz, Christian ; Römer, Lin ; Schierling, Martina ; M.Herold, Heike ; Slotta, Ute ; Spinetti, Thibaud ; Scheibel, Thomas ; Winter, Gerhard ; Bourquin, Carole ; Engert, Julia

In: Biomaterials, 2018, vol. 172, p. 105–115

The generation of strong T-cell immunity is one of the main challenges for the development of successful vaccines against cancer and major infectious diseases. Here we have engineered spider silk particles as delivery system for a peptide-based vaccination that leads to effective priming of cytotoxic T-cells. The recombinant spider silk protein eADF4(C16) was fused to the antigenic peptide...

Université de Fribourg

NAB2 is a novel immune stimulator of MDA-5 that promotes a strong type I interferon response

Oberson, Anne ; Spagnuolo, Lorenzo ; Puddinu, Viola ; Barchet, Winfried ; Rittner, Karola ; Bourquin, Carole

In: Oncotarget, 2018, vol. 9, no. 5, p. -

Novel adjuvants are needed to increase the efficacy of vaccine formulations and immune therapies for cancer and chronic infections. In particular, adjuvants that promote a strong type I IFN response are required, since this cytokine is crucial for the development of efficient anti-tumoral and anti-viral immunity. Nucleic acid band 2 (NAB2) is a double- stranded RNA molecule isolated from...

Université de Fribourg

Polymer-based nanoparticles loaded with a TLR7 ligand to target the lymph node for immunostimulation

Widmer, Jérôme ; Thauvin, Cédric ; Mottasa, Inès ; Nguyen, Van Nga ; Delie, Florence ; Allémann, Eric ; Bourquin, Carole

In: International Journal of Pharmaceutics, 2018, vol. 535, no. 1, p. 444–451

Small-molecule agonists for the Toll-like receptors (TLR) 7 and 8 are effective for the immunotherapy of skin cancer when used as topical agents. Their systemic use has however been largely unsuccessful due to dose-limiting toxicity. We propose a polymer-based nanodelivery system to target resiquimod, a TLR7 ligand, to the lymph node in order to focus the immunostimulatory activity and to...

Université de Fribourg

Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade

Secondini, Chiara ; Coquoz, Oriana ; Spagnuolo, Lorenzo ; Spinetti, Thibaud ; Peyvandi, Sanam ; Ciarloni, Laura ; Botta, Francesca ; Bourquin, Carole ; Rüegg, Curzio

In: OncoImmunology, 2017, vol. 6, no. 6, p. e1316437

Tumor angiogenesis promotes tumor growth and metastasis. Anti-angiogenic therapy in combination with chemotherapy is used for the treatment of metastatic cancers, including breast cancer but therapeutic benefits are limited. Mobilization and accumulation of myeloid-derived suppressor cells (MDSC) during tumor progression and therapy have been implicated in metastasis formation and resistance to...

Université de Fribourg

Antimicrobial silver-filled silica nanorattles with low immunotoxicity in dendritic cells

Priebe, Magdalena ; Widmer, Jérôme ; Löwa, Nina Suhartha ; Abram, Sarah-Luise ; Mottas, Inès ; Woischnig, Anne-Kathrin ; Brunetto, Priscilla S. ; Khanna, Nina ; Bourquin, Carole ; Fromm, Katharina M.

In: Nanomedicine: Nanotechnology, Biology and Medicine, 2017, vol. 13, no. 1, p. 11–22

The progression in the use of orthopedic implants has led to an increase in the absolute number of implant infections, triggering a search for more effective antibacterial coatings. Nanorattles have recently gained interest in biomedical applications such as drug delivery, as encapsulation of the cargo inside the hollow structure provides a physical protection from the surrounding...