Perfeziona i miei risultati

Architecture of lipid droplets in endoplasmic reticulum is determined by phospholipid intrinsic curvature

Choudhary, Vineet ; Golani, Gonen ; Joshi, Amit S. ; Cottier, Stéphanie ; Schneiter, Roger ; Prinz, William A. ; Kozlov, Michael M.

In: Current Biology, 2018, vol. 28, no. 6, p. 915-926.e9

Lipid droplets (LDs) store fats and play critical roles in lipid and energy homeostasis. They form between the leaflets of the endoplasmic reticulum (ER) membrane and consist of a neutral lipid core wrapped in a phospholipid monolayer with proteins. Two types of ER-LD architecture are thought to exist and be essential for LD functioning. Maturing LDs either emerge from the ER into the...