Perfeziona i miei risultati

Document type

Institution

Collection spécifique

Lingua

  • Inglese (2) disattivare il filtro

Parola chiave

    Università della Svizzera italiana

    Malectin participates in a backup glycoprotein quality control pathway in the mammalian ER

    Galli, Carmela ; Bernasconi, Riccardo ; Soldà, Tatiana ; Calanca, Verena ; Molinari, Maurizio

    In: Plos one, 2011, vol. 6, no. 1, p. e16304

    Malectin is a conserved, endoplasmic reticulum (ER)-resident lectin that recognizes high mannose oligosaccharides displaying terminal glucose residues. Here we show that Malectin is an ER stress-induced protein that selectively associates with glycopolypeptides without affecting their entry and their retention in the Calnexin chaperone system. Analysis of the obligate Calnexin client...

    Università della Svizzera italiana

    Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates

    Bernasconi, Riccardo ; Galli, Carmela ; Calanca, Verena ; Nakajima, Toshihiro ; Molinari, Maurizio

    In: The journal of cell biology, 2010, vol. 188, no. 2, p. 223–235

    Sophisticated quality control mechanisms prolong retention of protein-folding intermediates in the endoplasmic reticulum (ER) until maturation while sorting out terminally misfolded polypeptides for ER-associated degradation (ERAD). The presence of structural lesions in the luminal, transmembrane, or cytosolic domains determines the classification of misfolded polypeptides as ERAD-L, -M, or -C...