Université de Fribourg

Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling

Asparuhova, Maria B. ; Secondini, Chiara ; Rüegg, Curzio ; Chiquet-Ehrismann, Ruth

In: Molecular Oncology, 2015, vol. 9, no. 8, p. 1510–1527

Radiotherapy is a standard treatment after conservative breast cancer surgery. However, cancers relapsing within a previously irradiated area have an increased probability to metastasize. The mechanisms responsible for this aggressiveness remain unclear. Here, we used the clinically relevant 4T1 breast cancer model mimicking aggressive local relapse after radiotherapy to identify differences...