In: Journal Of The National Cancer Institute, 2015, vol. 107, no. 7, p. -
|
In: The Journal of Biochemistry, 1999, vol. 126, no. 6, p. 1136-1143
|
In: Journal Of The National Cancer Institute, 2013, vol. 105, no. 6, p. 393-404
|
In: Expert Reviews in Molecular Medicine, 2012, vol. 14, p. -
|
In: Nucleic Acids Research, 2005, vol. 33, p. W423-W426
|
In: Seminars in Cancer Biology, 2017, p. -
Chronic inflammation is a major cause of human cancer. Clinical cancer therapies against inflammatory risk factors are strategically determined. To rationally guide a novel drug development, an improved mechanistic understanding on the pathological connection between inflammation and carcinogenesis is essential. PI3K-PKB signaling axis has been extensively studied and shown to be one of the...
|
In: Cancer Discovery, 2012, vol. 2, no. 3, p. 248-259
Metastatic breast tumor cells display an epithelial–mesenchymal transition (EMT) that increases cell motility, invasion, and dissemination. Although the transcription factor Twist1 has been shown to contribute to EMT and cancer metastasis, the signaling pathways regulating Twist1 activity are poorly understood. Here, we show that Twist1 is ubiquitously phosphorylated in 90% of 1,532 invasive...
|
In: Science, 2002, vol. 15, no. 5562, p. 2088 - 2091
The phosphoinositide phosphatase PTEN is mutated in many human cancers. Although the role of PTEN has been studied extensively, the relative contributions of its numerous potential downstream effectors to deregulated growth and tumorigenesis remain uncertain. We provide genetic evidence in Drosophila melanogaster for the paramount importance of the protein kinase Akt [also called protein...
|
