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    Université de Fribourg

    Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer

    Lan, Qiang ; Peyvandi, Sanam ; Duffey, Nathalie ; Huang, Yu-Ting ; Barras, David ; Held, Werner ; Richard, François ; Delorenzi, Mauro ; Sotiriou, Christos ; Desmedt, Christine ; Lorusso, Girieca ; Rüegg, Curzio

    In: Oncogene, 2019, vol. 38, no. 15, p. 2814–2829

    Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER−) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however, there is no formal evidence for it. Here, we provide experimental...

    Université de Fribourg

    The matricellular protein CYR61 promotes breast cancer lung metastasis by facilitating tumor cell extravasation and suppressing anoikis

    Huang, Yu-Ting ; Lan, Qiang ; Lorusso, Girieca ; Duffey, Nathalie ; Rüegg, Curzio

    In: Oncotarget, 2016, vol. 8, no. 6, p. 9200–9215

    Matricellular proteins play multiple roles in primary tumor growth, local invasion and tumor angiogenesis. However, their contribution to metastasis and the putative mechanisms involved are less well characterized. In ER-negative human breast cancer, elevated expression levels of the matricellular protein Cysteine-rich angiogenic inducer 61 (CYR61) are associated with more aggressive...

    Université de Fribourg

    The matricellular protein CYR61 interferes with normal pancreatic islets architecture and promotes pancreatic neuroendocrine tumor progression

    Huang, Yu-Ting ; Lan, Qiang ; Ponsonnet, Lionel ; Blanquet, Marisa ; Christofori, Gerhard ; Zaric, Jelena ; Rüegg, Curzio

    In: Oncotarget, 2015, vol. 7, no. 2, p. 1663–1674

    The significance of matricellular proteins during development and cancer progression is widely recognized. However, how these proteins actively contribute to physiological development and pathological cancer progression is only partially elucidated. In this study, we investigated the role of the matricellular protein Cysteine-rich 61 (CYR61) in pancreatic islet development and carcinogenesis....