Università della Svizzera italiana

Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis

Hu, Dan ; Notarbartolo, Samuele ; Croonenborghs, Tom ; Patel, Bonny ; Cialic, Ron ; Yang, Tun-Hsiang ; Aschenbrenner, Dominik ; Andersson, Karin M. ; Gattorno, Marco ; Pham, Minh ; Kivisakk, Pia ; Pierre, Isabelle V. ; Lee, Youjin ; Kiani, Karun ; Bokarewa, Maria ; Tjon, Emily ; Pochet, Nathalie ; Sallusto, Federica ; Kuchroo, Vijay K. ; Weiner, Howard L.

In: Nature communications, 2017, vol. 8, p. 1600

We have previously reported the molecular signature of murine pathogenic TH17 cells that induce experimental autoimmune encephalomyelitis (EAE) in animals. Here we show that human peripheral blood IFN-γ+IL-17+ (TH1/17) and IFN-γ−IL-17+ (TH17) CD4+ T cells display distinct transcriptional profiles in high-throughput transcription analyses. Compared to TH17 cells, TH1/17 cells have gene...